High-speed X-ray phase contrast imaging of cavitation bubble cloud dynamics in a high-intensity focused ultrasound field

Exploiting X-ray phase contrast imaging, this proposal aims to extend our physical description of the cavitation bubble cloud dynamics in a high-intensity focused ultrasound (HIFU) field to the internal cloud dynamics. The expected comprehensive description will contribute to improve the use of HIFU in multiple medical applications. More specifically, we intend to conduct HIFU-cavitation bubble cloud experiments in (1) a boundary-free environment to describe the canonical dynamics of bubble clouds and (2) in a human body environment (using phantoms) to address the effect of boundaries on the cloud dynamics mimicking conditions in HIFU-based clinical therapies.