Azacryptands induce DNA damage
收藏NIAID Data Ecosystem2026-03-12 收录
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http://flowrepository.org/id/FR-FCM-Z3PY
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资源简介：
Study the mechanism of action of new ligand that binds to higher-order DNA structures, confirming that it induces DNA damage. We use a well-known DNA damage signalling molecule for immunostaining, a histone phosphorylation marker, gammaH2AX.
Conclusion:
We see that treatment of cells with azacryptands, TrisNP and TrisPOB, induce gammaH2AX signalling, indicating DNA damage is the main cause of cytotoxicity
Notes:
Experiments performed in PFA-fixed MCF-7 breat cancer cells. gammaH2AX staining and counter-staining with Anti-rabbit IgG Fab2 Alexa 647nm
创建时间：
2021-04-01
