Mild Silver(I)-Mediated Regioselective Iodination and Bromination of Arylboronic Acids

A convenient and regioselective silver(I)-mediated electrophilic iodination and bromination reaction of arylboronic acids has been developed. The boronic acid does not require protection prior to the reaction, which can be performed on a multigram scale with moderate to excellent yields. A mild, simple, and effective method is disclosed to provide ortho-haloarylboronic acids that can be used as useful intermediates in selective sequential Suzuki−Miyaura cross-coupling reactions to provide ortho-triaryl derivatives in good yields.