Distinct prefrontal projections oppositely orchestrate social competition and hierarchy
收藏Alliance of Genome Resources2026-08-01 收录
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The medial prefrontal cortex (mPFC) is known as a hub of social hierarchy determination in the brain, Using high throughput single cell transcriptomic analysis and projection-specific genetic manipulation, we discovered that the expression level of Pou3f1 in mPFC-VTA neurons controls social hierarchy. mPFC from social dominants (R1, n=5) and subordinates (R4, n=5) tissue punches were collected and dissected, and the resulting cells were subjected to a 10X Genomics scRNA-seq pipeline
