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Synthesis of CMe2CF3‑Containing Heteroarenes via Tandem 1,1-Dimethyltrifluoroethylation and Cyclization of Isonitriles

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Figshare2018-12-04 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Synthesis_of_CMe_sub_2_sub_CF_sub_3_sub_Containing_Heteroarenes_via_Tandem_1_1-Dimethyltrifluoroethylation_and_Cyclization_of_Isonitriles/7416167
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A tandem 1,1-dimethyltrifluoroethylation and cyclization of isonitriles with 3,3,3-trifluoro-2,2-dimethylpropanoic acid was developed. This protocol provides the efficient synthesis of a series of previously unknown CMe2CF3-containing heteroarenes, which are potentially useful in the drug discovery process.
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2018-12-04
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