Genotyping of additional Inflammatory Bowel Disease cases 2014

Both internal and external funding has enabled 5000 inflammatory bowel disease cases to be
whole genome sequenced (CD @4X, UC @2X). The Anderson and Barrett groups are
currently generating genotypes across these samples for comparison to 4000 population
controls sequenced as part of UK10K. The UK10K project has shown that imputing
sequenced genetic variation into previously GWASed samples greatly increases power to
detect association. Given that our study has been designed to detect association to low
frequency variation (0.5% and above) these gains in power are especially important. Overall,
the UKIBDGC has GWAS data for around 1800 CD samples (Affy 500K) and 3000 UC
samples (Affy6), though some of these samples have also been whole genome sequenced.
Here, we apply to get all remaining non-GWAS and non-WGS IBD cases in the UKIBDGC
(N=X) genotyped genotyped on the Illumina Core Exome ArrayEGA study EGAS00001000924