ATAC-seq datasets for chromatin accessibility quantification in "Enhancer RNAs predict enhancer-gene regulatory links and are critical for enhancer function in neuronal systems"

This dataset contains Assay for Transposase-Accessible Chromatin (ATAC) sequencing results from rat embryonic cortical, hippocampal, and striatal neuronal cultures treated with either vehicle (complete Neurobasal media) or potassium chloride (10mM) for 1hr. Overall design: This experiment contains 18 biological samples, each of which underwent ATAC-seq on an Illumina NextSeq500 instrument. Samples were treated with neurobasal media (vehicle; samples V1C, V2C, V3C, V1H, V2H, V4H, V1S, V2S, V4S), or 10mM KCl (samples K2C, K3C, K4C, K1H, K2H, K4H, K1S, K2S, K3S) . The first letter of sample names denotes acute treatement (V = vehicle, K = KCl). The second digit denotes the unique replicate ID for a given brain region and treatment. The third digit denotes the region of cultured neuron (C = cortex, H = hippocampus, S = striatum). Forward and reverse paired-end reads are denoted as "R1" or "R2" in raw file names.