Shotgun metagenomics of the Thy1-SYN transgenic mouse model of Parkinson's disease

Using shotgun metagenomics, we longitudinally characterized the gut microbiome of the Thy1-SYN (line 61) transgenic (TG) mouse model of Parkinson's disease (PD), which over expresses wild-type human alpha-synuclein, to test how the gut microbiome composition responds to PD pathology during aging. Fecal pellets were collected at four time points (1, 3, 6, and 12 months) from 22 TG and 32 non-TG mice across 22 litters (total analytical sample N = 216).