Tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis: a model for precision nephrology

Reporter genes for TNF activation have not been studied in nephrotic syndrome cases at the single nuclear RNA-seq level. Use of archived kidney biopsy material that was fragmented into individual nuclei and assayed for presence of genes involved in TNF activation in patients predicted to have high or low expression of these genes. RNAlater-preserved, archived kidney biopsies were subjected to single nuclear RNA-sequencing Raw data not provided due to patient privacy concerns