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A Protocol for an Asymmetric Synthesis of γ-Amino Acids

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Figshare2016-02-20 更新2026-04-29 收录
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https://figshare.com/articles/dataset/A_Protocol_for_an_Asymmetric_Synthesis_of_Amino_Acids/2503465
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A new and practical method for the asymmetric synthesis of γ-amino acids from β,γ-butenolides by an in situ esterification, condensation, and reduction in a one-pot procedure is described. This method is quite general for the preparation of both enantiomers of aryl or aliphatic γ-amino acids in high yields. These γ-amino-acid derivatives were also shown to be versatile synthetic intermediates for further transformations by their conversion to γ-lactams, δ-amino alcohols, and hydrolysis products in high yields with no racemization.
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2016-02-20
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