An atlas of pancreatic function for ruminating goats mapped by single cell transcriptomics. An atlas of pancreatic function for ruminating goats mapped by single cell transcriptomics

The objectives of this study were to elucidate the development of pancreatic function from the non-ruminating to ruminating stage, including characterizing the inventory of cell types and their corresponding marker genes in the pancreas, using single-cell transcriptomic techniques.Pancreas of adult twin female goats at ruminating stage were collected after harvesting and the pancreas of neonatal twin female goats at non-ruminating stage were used as control. Overall design: Four Liuyang black goats aged of 10 days old (neonatal goats at non-ruminating stage) and 6 months old (adult goats at ruminating stage) were selected from commercial goat farms and divided into XY group (10-days old, n=2, control) and DY group (6-months old, n=2), respectively. Goats were humanely euthanized, and the pancreas was freshly sampled.