Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor Y13158
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Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor Y13158 Descriptor: 1,2-ETHANEDIOL, 7-[2-[2,4-bis(fluoranyl)phenoxy]-5-(2-oxidanylpropan-2-yl)phenyl]-2-[4-(2-hydroxyethyloxy)-3,5-dimethyl-phenyl]-5-methyl-furo[3,2-c]pyridin-4-one, DI(HYDROXYETHYL)ETHER, ... Authors: Li, J, Zhang, C, Xu, H, Zhuang, X, Wu, X, Zhang, Y, Xu, Y. Deposit date: 2022-01-18 Release date: 2022-08-10 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.12 Å) Cite: Structure-Based Discovery and Optimization of Furo[3,2- c ]pyridin-4(5 H )-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors. J.Med.Chem., 65, 2022
创建时间：
2022-01-18
