Bead_Diffusion_Simulation_Data.dat

Computer simulations of 2-dimensional bead diffusion and binding to fibrin were conducted. Simulations were run with MATLAB R2016a software using custom code. The simulation domain was a 2 mm by 2 mm box with reflecting boundary conditions on the top, left, and right, and with an absorbing boundary condition on the bottom. The bottom of the domain represented a fibrin fiber, and hence the absorbing boundary condition modeled irreversible binding of the beads to the fiber. The domain was partitioned into a grid using space steps of 0.02 mm in both the x- and y-directions. In a single simulation, 100 beads (20 nm diameter) were uniformly and randomly distributed on grid nodes in the top half of the simulation domain. At each time step, each bead could remain at its current grid node or move to one of the 4 nearest neighbor grid nodes, with equal probability. The time step, 1x10-5 s, was approximated from the diffusion coefficient of a 24 nm diameter bead (D»1x10-7 cm2/s) and the 0.02 mm space step. Each simulation was run for 60 seconds of simulation time. 500 independent simulations were run, and data was collected about if/when and where each bead bound to the fiber