Co-expression clusters and Gene Ontology (GO) categories that change correlation with age at the top 1 percentile.

aThe percentile is calculated as the percent of permutation that exceeds the true correlation difference. The percentile corresponds to 100×[one-tailed p-value. Gene groups marked with a * indicate that the correlation is increasing with age.
bIf a co-expression cluster is enriched for genes in a GO category, genes in a KEGG category, or genes that share a protein motif from the Interpro (IPR) database, then the associated category is listed [48],[49].
cThe p-value for enrichment is calculated using the hypergeometric distribution (see Materials and Methods).