Curcumin is comparable to metformin for the treatment of PCOS in rats: a preclinical study. Weights and biochemical data

Background: Ploy cystic ovary syndrome (PCOS) is a common gynecological disorder affecting between 4-20% of females worldwide. Curcumin, the active ingredient in turmeric (Curcuma longa Zingiberaceae) is a yellow polyphenol with a wide range of pharmacological activities such as antioxidant, anti-inflammatory, anti-tumor, neuroprotective and cardioprotective properties. 
Methods: Letrozole was used to induce PCOS in female Wistar rats. Curcumin, metformin, or a combination of both was given to assess their therapeutic effects. Body weight, estrogen, progesterone, testosterone, and glucose levels were measured after disease induction and at the conclusion of treatment. Additionally ovarian histomorphology was examined after sacrificing the animals and removal of the ovaries.
Results and conclusion: Weight was significantly reduced in the curcumin, metformin and curcumin and metformin combination groups. Testosterone was decreased, progesterone was increased, and normal ovarian morph..., Study design
PCOS Induction
Six weeks old female rats were randomly divided into five groups; group one (n=17), served as control group, received 2 ml/kg of 1% CMC solution via oral gavage. Groups two to five (n=16 each); treatment groups, received 1mg/kg of letrozole dissolved in 1% CMC solution (2ml/kg) via oral gavage daily for 21 days (Kafali et al. 2004).
PCOS Treatment
After PCOS induction using letrozole, animals in groups two to five received treatment for a period of 20 days as follows; group 2 received metformin solution 500 mg/kg via oral gavage, group 3 received 100mg/kg curcumin dissolved in olive oil as oral drops, group 4 received a combination of 100 mg/kg curcumin oral drops and 500 mg/kg metformin oral gavage, while group 5 served as control group, received 2ml/kg olive oil oral drops.
The doses of metformin (Lemos et al. 2014), and curcumin (Nonose et al. 2014) were used based on previous studies.
Biochemical analysis
Body weight was measured every three days until t..., , # Data from: Curcumin is comparable to metformin for the treatment of PCOS in rats: a preclinical study. Weights and biochemical data

Dataset DOI: [10.5061/dryad.brv15dvgx](https://doi.org/10.5061/dryad.brv15dvgx)

## Description of the data and file structure

The data for this research uploaded as CSV files. Three separate files are uploaded

### **Data_for_repository-info.csv**

experimental groups defined and characterized as follows:

| Group number  | disease induction  | Treatment  |
| :------------ | :----------------- | :------------------- |
| I  | CMC  | CMC  |
| II  | CMC  | CMC  |
| III  | Letrozole  | Metformin  |
| IV  | Letrozole  | Metformin  |
| V  | Letrozole  | Curcumin  |
| VI  | Letrozole  | Curcumin  |
| VII  | Letrozole  | Metformin +Curcumin  ..., ,