Mean profiles scores.

Details of the profile scores of four gene sets that we predict may have a higher score than would be expected by random chance. These gene sets are: HCV-linked cellular receptors and lipoproteins, the majority of which facilitate virus entry (but also particle formation and release, here labeled “receptors”), host factors that we isolate from vesicles that harbour the HCV replication complex (HRFs), host factors that are required for HCV replication determined by siRNA screen (HDFs) and HCV interacting proteins (HCV interacting). For each gene set we show the mean profile score and the significance of the score enrichment, determined by Mann Whitney U test permutation. For all gene sets other than HDFs, the profile scores are on average greater than we would expect by random chance, given a p-value cutoff of