Enrichment analyses using look-up data for the 15 age-group specific BMI loci.

a One-sided binomial P-values that test for enrichment of nominal significant and directionally consistent association in the look-up data.b For the BMI increasing alleles of the 11 SNPs with stronger effect on BMI in ≤50y, we expect to see a nominal significant association with increased birth weight, increased risk for childhood obesity and increased BMI in the 16–25y age-group.c For the BMI increasing alleles of the 11 SNPs with stronger effect on BMI in ≤50y, we expect to see a nominal significant association with negative effect on weight change (weight loss), and for the BMI increasing alleles of the four SNPs with stronger effect on BMI in >50y, we expect to see a nominal significant association with positive effect on weight change (weight gain) (see Methods for details).The look-up data is taken from the EGG consortium for birth weight and for childhood obesity, and from personal communication for weight change trajectories. More details including SNP specific effect sizes or odds ratios and association P-Values on the look-up trait can be found in S15 Table (for birth weight), S16 Table (for childhood obesity) and S18 Table (for weight change).