Crystal Structure of Ivosidenib-resistant IDH1 variant R132C S280F in complex with NADPH and inhibitor DS-1001B
收藏Protein Data Bank Japan2024-10-09 更新2026-04-25 收录
下载链接：
https://pdbj.org/mine/summary/7pjn
下载链接
链接失效反馈官方服务：
资源简介：
Crystal Structure of Ivosidenib-resistant IDH1 variant R132C S280F in complex with NADPH and inhibitor DS-1001B Descriptor: (E)-3-(1-(5-(2-fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)isoxazole-4-carbonyl)-3-methyl-1H-indol-4-yl)acrylic acid, CITRIC ACID, GLYCEROL, ... Authors: Reinbold, R, Rabe, P, Abboud, M.I, Schofield, C.J, Clifton, I.J. Deposit date: 2021-08-24 Release date: 2022-07-13 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors. Nat Commun, 13, 2022
创建时间：
2021-08-24
