Effect estimates of the strongest interacting SNP from each nominally significant gene on FEV₁/FVC decline (n = 650).

SNP-estimates are based on an additive model. Beta-estimates represent percentages of decline in FEV1/FVC over 11 years per effect allele and/or for an exposure contrast of one interquartile range (IQR). All estimates are taken from the same interaction model. Positive values mean an attenuation, and negative ones an acceleration of FEV1/FVC decline. Rows are sorted according to ascending interaction p-values. *significant after Bonferroni correction for testing 12679 SNPs (α = 3.9×10E-6). gen: genotyped SNP; imp: imputed SNP; All1: allele 1 (effect allele); All2: allele 2 (baseline allele); FreqAll1: frequency of allele 1.