Supplemental Table 1. Quality Control Data from Bulk-Tissue RNA-Sequencing

QC data from sequencing that was performed in two batches at the Mellowes Center for Genomic Sciences and Precision Medicine ‘Omics Core (RRID:SCR_022926). RNA was isolated using the Qiagen RNeasy Lipid Tissue Kit (Qiagen, Hilden, Germany), per the manufacturer’s recommendations, including on-column DNase digestion. Extracted RNA as quantified using Qubit Fluorometer(Thermo Fisher Scientific, Waltham, MA) and quality assed with a Fragment Analyzer 5200 (RRID:SCR_019417). RNA-seq libraries were constructed using the SMART-SEQ v4 Ultra Low Input RNA Kit for Sequencing (Takara Bio, San Jose, CA) and the Nextera XT DNA Library Preparation Kit (Illumina, San Diego, CA), per the manufacturer’s recommendations. Library quality was assessed with the Fragment Analyzer 5200 (RRID:SCR_019417), quantitative PCR, and MiSeq Nano QC (50-cycle run). Paired-end sequencing (2 × 100 bp) was performed on an Illumina NovaSeq 6000 S1 Flowcell (200 cycle, Illumina, San Diego, CA) with a target of ∼40 million total reads per sample.