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B cell-intrinsic STAT6 controls the germinal center response in type 2 immunity

ChEBI2014-05-26 更新2026-07-21 收录

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STAT信号通路

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-47679 数据链接链接失效反馈

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资源简介：

B cell-intrinsic STAT6 controls the germinal center response in type 2 immunity

应用场景：

创建时间：

2014-05-26

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基因缺陷模型

Analyze kinetics, cell composition and proliferation of germinal center B cells in wt vs Ung-/- vs Aicda-/- vs Ung-/- Aicda-/- mice after immunization with model antigens.

NIAID Data Ecosystem80

The sequence of linear and conformational B-cell epitopes of seven selected outer membrane proteins from P. aeruginosa strain 24Pae112.

病原体外膜蛋白表位

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The sequence of linear and conformational B-cell epitopes of seven selected outer membrane proteins from P. aeruginosa strain 24Pae112.

Figshare2023-08-03 更新30

IL-21 Shapes the B Cell Response in a Context-Dependent Manner [RNA-seq

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细胞信号传导

The cytokine interleukin-21 (IL-21) is a pivotal T cell-derived signal crucial for germinal center (GC) responses, but the precise mechanisms by which IL-21 influences B cell function remain elusive.

NIAID Data Ecosystem20

CD28 deficiency leads to accumulation of germinal-center independent IgM + experienced B cells and to production of protective IgM during experimental malaria

感染免疫学

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Protective immunity to blood-stage malaria is attributed to Plasmodium-specific IgG and effector-memory T helper 1 (Th1) cells. However, mice lacking the costimulatory receptor CD28 (CD28KO) maintain

NIAID Data Ecosystem60

Toll-like receptor mediated inflammation directs B cells towards protective antiviral extrafollicular responses

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抗病毒机制

Flow cytometry, ELISA, ELISPOT analyses

Figshare2023-07-06 更新20