The KINOMEscan assay platform is based on a competition binding assay that is run for a compound of interest against each of a panel of 317 to 456 kinases. The assay has three components: a kinase-tag
*SC-1 was evaluated for in vitro kinase inhibition utilizing a miniaturized 33P-based screening assay [41]. The maximum concentration tested was 10 µM. IC50 (inhibitory concentration of 50% of the con
Oxidosqualene cyclase (OSC), a membrane-associated protein, is a key enzyme of sterol biosynthesis. Here we report a novel assay for OSC, involving reaction in aqueous solution, NMR quantification in