H2-M2

Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Located in cell surface. Is expressed in several structures, including brain; genitourinary system; immune system; integument; and liver. Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-E (major histocompatibility complex, class I, E). [provided by Alliance of Genome Resources, Nov 2024]

本数据集预测该基因能够激活多种功能，包括14-3-3蛋白结合活性、TAP蛋白结合活性和信号受体结合活性。预测该基因参与多种过程，包括通过内质网途径、TAP非依赖性MHC I类途径处理和呈递内源性肽抗原，MHC Ib类途径处理和呈递内源性肽抗原，以及正向调节T细胞介导的细胞毒性。该基因位于细胞表面，在多个结构中表达，包括大脑、泌尿生殖系统、免疫系统、表皮和肝脏。该基因的人类同源基因与多种疾病相关，包括史蒂文斯-约翰逊综合征、哮喘（多例）、自身免疫性疾病（多例）、眼部疾病（多例）和内耳疾病（多例）。与包括HLA-B（主要组织相容性复合体I类B）、HLA-C（主要组织相容性复合体I类C）和HLA-E（主要组织相容性复合体I类E）在内的多个人类基因同源。[由基因组资源联盟提供，2024年11月]