Lactococcus cremoris strain:ASCC892185 Genome sequencing. Lactococcus cremoris strain:ASCC892185

Title: Understanding the role of c-di-AMP in lysis in Lactococcus.This project aims to investigate the cyclic-di-AMP signalling system in the main cheese fermentation bacterium Lactococcus. The recently discovered cyclic-di-AMP is essential for normal bacterial growth and plays key roles in heat and antibiotic resistance, metabolism and virulence. The specific aims of this project is to determine how the c-di-AMP level affects cell lysis and antibiotic resistance in Lactococcus.Expected outcomes include a much deeper understanding of signalling inputs and outputs of c-di-AMP. This should lead to benefits such as guiding the improvement of bacterial strains used in food and biochemical biotechnological applications, and may provide the foundation for the development of novel antibiotics.