Paternal high-fat diet affects weight and DNA methylation of their offspring

paternal transmission of CpG methylation Overall design: First-generation male Wistar rats were fed either a high-fat diet (HF) or chow and were mated with females fed chow. The resulting offspring were raised on a chow diet until day 35, after which they underwent a dietary challenge. Methylation at the hypothalamic Arc nucluse was analysed using RRBS