five

TCR affinity-dependent functional inhibition via PD-1 and SHP-1 phosphatase

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE42922
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To investigate gene expression changes associated with stimulation of TCRs of different affinity, primary CD8 T cells were transduced with sequence optimized TCRs of various affinities and stimulated for 6h. Gene expression was measured at baseline (0h) and after 6h after stimulation with low dose NY-ESO-1 multimer
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2019-01-23
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