Mid-gestation serum lipidomic profile of PTB are influenced by BMI

BMIs is one of risk factors for spontaneous preterm birth (sPTB). To identify BMI-associated metabolic perturbations and potential mid-gestation serum biomarkers of sPTB, the study compared metabolomics/lipidomics in sPTB and FTB (Full term birth) women stratified by BMIs categories: underweight, normal weight, and obese. Technique: combining untargeted metabolomics and lipidomics with targeted metabolic profiling of major regulators of inflammation and metabolism, including oxylipins, endocannabinoids, bile acids and ceramides. Results: 1) underweight/sPTB showed dyslipidemia characterized by elevated phospholipids, unsaturated triglycerides, sphingomyelins, cholesteryl esters and long-chain acylcarnitines. 2) normalweight/sPTB showed altered relative abundance of 14(15)-epoxyeicosatrienoic acid and 14,15-dihydroxyeicosatrienoic acids to other regioisomers at mid-pregnancy. 3) obese/sPTB: showed elevated oxidative stress and dyslipidemia characterized by elevated serum free fatty acids. In conclusion, using metabolomics can distinct BMI-dependent metabolic manifestations among women who had sPTB