DeCaluwe2016 - Circadian Clock

DeCaluwé2016 - Circadian Clock

This model is described in the article:

A Compact Model for the
Complex Plant Circadian Clock.

De Caluwé J, Xiao Q, Hermans C,
Verbruggen N, Leloup JC, Gonze D.
Front Plant Sci 2016; 7: 74
Abstract:

The circadian clock is an endogenous timekeeper that allows
organisms to anticipate and adapt to the daily variations of
their environment. The plant clock is an intricate network of
interlocked feedback loops, in which transcription factors
regulate each other to generate oscillations with expression
peaks at specific times of the day. Over the last decade,
mathematical modeling approaches have been used to understand
the inner workings of the clock in the model plant Arabidopsis
thaliana. Those efforts have produced a number of models of
ever increasing complexity. Here, we present an alternative
model that combines a low number of equations and parameters,
similar to the very earliest models, with the complex network
structure found in more recent ones. This simple model
describes the temporal evolution of the abundance of eight
clock gene mRNA/protein and captures key features of the clock
on a qualitative level, namely the entrained and free-running
behaviors of the wild type clock, as well as the defects found
in knockout mutants (such as altered free-running periods, lack
of entrainment, or changes in the expression of other clock
genes). Additionally, our model produces complex responses to
various light cues, such as extreme photoperiods and non-24 h
environmental cycles, and can describe the control of hypocotyl
growth by the clock. Our model constitutes a useful tool to
probe dynamical properties of the core clock as well as
clock-dependent processes.

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