The role and mechanism of GSDME in cisplatin induced renal tubular epithelial cells injury (PRJCA025787)

Recently, Gasdermin family has attracted considerable attention and its classical molecule GSDMD has been shown to exacerbate cisplatin renal injury by promoting renal tubular epithelial cell death and inflammatory response. As a member of the Gasdermin family, GSDME is abundantly expressed in renal tubular epithelial cells, but the function diversity of GSDME needs further investigation, and whether it plays a role in cisplatin-induced renal injury remain to be elucidated.