IRF4/BATF and interleukin-33 orchestrate development and maintenance of adipose tissue resident regulatory T cells
收藏Alliance of Genome Resources2026-08-01 收录
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To understand the differentiation of effector Tregs in more detail, we have performed transcriptional profiling of central Tregs and effector Tregs, based on Blimp1 expression. We performed RNA-sequencing of Foxp3+ regulatory T cells, comparing Blimp1/GFP+ and Blimp1/GFP- cells Three biologically independent samples for each condition were sequenced (condition 1: CD4+ CD25high Blimp1/GFP+; condition 2: CD4+ CD25high Blimp1/GFP-); cells were sorted from pooled spleens and lymph nodes of Blimp1/GFP reporter mice
