Genes encoding subunits of SWI/SNF chromatin remodeling complexes are collectively mutated in ~20% of all human cancers. Although ARID1A is the most frequent target of mutations, the mechanism by whic

NIAID Data Ecosystem30

Dietary Heme Alters Microbiota and Mucosa of Mouse Colon without Functional Changes in Host-Microbe Cross-Talk

消化道微生物组

结肠癌机制

Colon cancer is a major cause of cancer deaths in Western countries and is associated with diets high in red meat. Heme, the iron-porphyrin pigment of red meat, induces cytotoxicity of gut contents wh

Figshare2016-01-19 更新20

Altered interactions between the gut microbiome and colonic mucosa precede polyposis in APCMin/+ mice. Mus musculus

消化道微生物组

结肠癌机制

Mutation of the adenomatous polyposis coli (APC gene), an early event in the adenoma-carcinoma sequence, is present in 70-80% of sporadic human colorectal adenomas and carcinomas. To test the hypothes

NIAID Data Ecosystem70

Pathway and single gene analysis of Caco-2 cell differentiation by ascorbate-stabilized quercetin

结肠癌机制

细胞分化基因表达

The aim was to investigate mechanisms contributing to quercetin’s previously described effects on cell-proliferation and -differentiation, which contradicted its proposed anti-carcinogenic potency. In

NIAID Data Ecosystem30