ALK upregulates POSTN and WNT signaling to drive neuroblastoma

The goal of this study is to identify the mechanism for how ALK promotes tumorigenesis in neuroblastoma. We developed a human stem cell model of neuroblastoma and generated isogenic tumors using MYCN and MYCN/ALK. RNAseq analysis of both tumors revealed an enrichment in focal adhesion signaling and allowed us to find POSTN as a key mediator of ALK-mediated tumor growth. The samples are human stem cell derived trunk neural crest cells that were implanted into mice and developed into tumors. We have samples of WTC11 MYCN, WTC11 MYCN/ALK and 1323 MYCN tumors. The data provided is RNA-seq analysis of each of the samples in triplicate