Spatial transcriptomics data of mouse thymus

The thymus is a critical organ for T cell development and immune system function, but it undergoes significant structural and functional changes during aging, a process known as thymic involution. To investigate the spatial and cellular changes associated with thymic aging, we performed single-cell spatial transcriptomics on thymic tissues from young (4-week-old) and aged (52-week-old) C57BL/6J mice, with three biological replicates per age group. This dataset provides a detailed spatial and cellular map of the thymus at single-cell resolution, capturing changes in cell types, abundances, and spatial organization during aging. The results offer valuable insights into the cellular and spatial heterogeneity of the thymus and provide a resource for understanding immune system aging and potential therapeutic strategies.

胸腺是支持T细胞发育与维持免疫系统功能的关键器官，但在衰老进程中会发生显著的结构与功能改变，这一过程被称为胸腺退化（thymic involution）。为探究与胸腺衰老相关的空间及细胞层面变化，我们对4周龄年轻小鼠与52周龄衰老小鼠的胸腺组织开展了单细胞空间转录组学检测，每个年龄组设置3次生物学重复。本数据集提供了单细胞分辨率下胸腺的精细空间与细胞图谱，捕捉到衰老过程中细胞类型、细胞丰度及空间组织模式的变化。该研究结果可为解析胸腺的细胞与空间异质性提供重要见解，同时为理解免疫系统衰老机制及开发潜在治疗策略提供宝贵的研究资源。

搜集汇总

背景与挑战

背景概述

该数据集提供了年轻和年老C57BL/6J小鼠胸腺的单细胞空间转录组数据，包含每组三个生物学重复。它通过单细胞分辨率的空间和细胞图谱，揭示了胸腺衰老过程中细胞类型、丰度及空间组织的动态变化，为理解免疫系统衰老和潜在治疗策略提供了重要资源。