PGM2:Mg2+ isomerises dR1P to dR5P

The nucleoside breakdown product deoxyribose-1-phosphate (dR1P) can be used to produce energy during oxidative or mitochondrial stress to minimize or delay stress-induced damage. Two steps connect this nucleoside breakdown product to central carbon metabolism in mammals. In the first step, dR1P is isomerised to the corresponding 5-phosphopentose, dR5P, mediated by phosphoglucomutase-2 (PGM2). PGM2 is a cytosolic, M2+-dependent enzyme that acts ten times better as a phosphopentomutase (both on R1P and dR1P) than as a phosphoglucomutase (on glucose-1-phosphate) (Maliekal et al. 2007).

核苷酸降解产物脱氧核糖-1-磷酸（dR1P）在氧化应激或线粒体应激期间可用于产生能量，以最小化或延迟应激诱导的损伤。该核苷酸降解产物与哺乳动物中的中心碳代谢之间通过两个步骤相联系。在第一步中，dR1P通过磷酸葡萄糖变位酶-2（PGM2）催化转化为相应的5-磷酸戊糖，即dR5P。PGM2是一种细胞质中的M2+-依赖性酶，其在作为磷酸戊糖异构酶（对R1P和dR1P均有效）方面的效率是作为磷酸葡萄糖变位酶（对葡萄糖-1-磷酸有效）的十倍（Maliekal等，2007年）。