Acid tolerance mechanism of Streptococcus mutans+transcriptomics

Significance and Purpose: Streptococcus mutans is a major cariogenic bacterium, and its strong acid resistance is crucial for causing dental caries. Our research found that SmFtsZ, which mediates cell division in S. mutans, is more active in acidic environments and is closely related to bacterial acid resistance. However, the mechanisms behind this remain unclear. Understanding how SmFtsZ regulates S. mutans' acid resistance and cariogenicity will provide insights into these mechanisms and potential targets for small molecule inhibitors, offering new strategies for clinical caries control.