Adaptive optical imaging with entangled photons

Adaptive optics (AO) has revolutionized imaging in fields from astronomy to microscopy by correcting optical aberrations. In label-free microscopes, however, conventional AO faces limitations due to the absence of guidestar and the need to select an optimization metric specific to the sample and imaging process. Here, we propose an AO approach leveraging correlations between entangled photons to directly correct the point spread function (PSF). This guidestar-free method is independent of the specimen and imaging modality. We demonstrate the imaging of biological samples in the presence of aberrations using a bright-field imaging setup operating with a source of spatially-entangled photon pairs. Our approach performs better than conventional AO in correcting specific aberrations, particularly those involving significant defocus. Our work improves AO for label-free microscopy and could play a major role in the development of quantum microscopes., , , # Adaptive optical imaging with entangled photons

[https://doi.org/10.5061/dryad.cnp5hqccd](https://doi.org/10.5061/dryad.cnp5hqccd)

Dataset includes all experimental data presented in the figures of the main article. Context and experimental procedure are described in the article.

Fig 3a: Direct intensity reference image of a honeybee mouthpiece. No aberrations present in the system and no correction displayed on SLM.
Fig 3b: Blurred direct intensity image of honeybee with aberrations. No correction displayed on SLM.
Fig 3c: Corrected direct intensity image of honeybee with aberrations and correction displayed on SLM.
Fig 3d: Sum-coordinate projection showing the spatial structure of photon pairs' correlations. From same acquisition as Fig 3a. No aberrations and no correction on SLM.
Fig 3e: Sum-coordinate projection in the presence of aberrations. From same acquistion as Fig 3b. No correction on SLM.
Fig 3f: Sum-coordinate projection after correction. From same acquisition as Fig 3...