Gene expression profile of colorectal cancer cell Caco-2 after OCC-1 knockdown

OCC-1 is one of the earliest annotated long noncoding RNAs (lncRNAs) in colorectal cancer (CRC). In our study, we found that knockdown of OCC-1 by shRNAs promotes CRC cell growth both in vitro and in vivo. To gain insight into the molecular function of OCC-1, we profiled the gene expression of Caco-2 cells after OCC-1 knockdown by microarray. OCC-1 was knockdown by two independent shRNAs, shOCC-1-1 and -2, in Caco-2 cells. The change of gene expression was determined relative to a non-target shRNA control, shCTRL. Overlapped differentially expressed genes in shOCC-1-1 and -2 cells were considered as OCC-1 regulated genes.