Data_Sheet_1_Effects of vibration training on motor and non-motor symptoms for patients with multiple sclerosis: A systematic review and meta-analysis.ZIP

BackgroundVibration therapy is one of the rehabilitation programs that may be effective in treating both motor and non-motor symptoms in Multiple Sclerosis patients. We conducted a comprehensive systematic review and meta-analysis to assess the effects of vibration therapy on motor and non-motor symptoms (functional mobility, balance, walking endurance, gait speed, fatigue, and quality of life) of this population.MethodsA systematic search of PubMed, Embase, the Cochrane Library, Web of Science, Physiotherapy Evidence Database, Scopus, Google Search Engine, and the China National Knowledge Infrastructure (CNKI). Two reviewers independently assessed the study quality.ResultsFourteen studies with 393 participants were finally included in the meta-analysis. The pooled results showed that vibration therapy had a significant advantage over the control intervention in improving balance function [mean difference (MD) = 2.04, 95% confidence interval (CI): 0.24–3.84, P = 0.03], and walking endurance (SMD = 0.34, 95% CI: 0.07–0.61, P = 0.01). Meanwhile, the degree of disability subgroup analysis revealed that the Expanded Disability Status Scale (EDSS) score (3.5–6) significantly improved functional mobility (MD: −1.18, 95% CI: −2.09 to 0.28, P = 0.01) and balance function (MD: 3.04, 95% CI: 0.49–5.59, P = 0.02) compared with the control group, and the EDSS (0–3.5) were more beneficial in walking endurance. The duration subgroup analysis indicated a significant difference in the effect of the duration (

背景振动疗法系一种可能对治疗多发性硬化症患者之运动及非运动症状有效的康复治疗方案。本研究通过全面系统综述与荟萃分析，评估振动疗法对此类人群运动及非运动症状（包括功能性活动能力、平衡能力、步行耐力、步态速度、疲劳感及生活质量）的影响。研究方法包括对PubMed、Embase、Cochrane图书馆、Web of Science、物理治疗证据数据库、Scopus、谷歌搜索引擎以及中国知网（CNKI）的系统性检索。两位评审员独立评估了研究质量。结果：最终纳入荟萃分析的14项研究共涉及393名参与者。荟萃分析结果显示，振动疗法在改善平衡功能方面相较于对照组具有显著优势[平均差异（MD）= 2.04，95%置信区间（CI）：0.24–3.84，P = 0.03]，以及在步行耐力（SMD = 0.34，95% CI：0.07–0.61，P = 0.01）方面亦表现出显著效果。同时，残疾程度亚组分析显示，与对照组相比，扩展残疾状态量表（EDSS）评分（3.5–6）显著改善了功能性活动能力（MD：−1.18，95% CI：−2.09至0.28，P = 0.01）及平衡功能（MD：3.04，95% CI：0.49–5.59，P = 0.02），而EDSS（0–3.5）在步行耐力方面则显示出更多益处。持续时间亚组分析表明，在持续时间方面，振动疗法的效果存在显著差异。