CancerPPD: a database of anticancer peptides and proteins

CancerPPD is a comprehensive database of experimentally validated anticancer peptides (ACPs) and anticancer proteins developed to support peptide-based cancer therapeutics research. The database integrates detailed information about peptide sequences, structures, modifications, cancer cell line activity, and bioinformatics analysis tools. Web Server: https://webs.iiitd.edu.in/raghava/cancerppd/ Citation Tyagi, A., Tuknait, A., Anand, P., Gupta, S., Sharma, M., Mathur, D., Joshi, A., Singh, S., Gautam, A., & Raghava, G. P. S. (2015). CancerPPD: a database of anticancer peptides and proteins. Nucleic Acids Research, 43(Database issue), D837–D843. https://doi.org/10.1093/nar/gku892 About the Database CancerPPD was developed to systematically collect and organize experimentally verified anticancer peptides and proteins reported in scientific literature, patents, and public databases. Anticancer peptides are emerging therapeutic molecules due to their cancer-selective toxicity, high specificity, low intrinsic toxicity, and ability to overcome multidrug resistance. The database contains curated information regarding peptide sequences, physicochemical properties, structural information, biological activity, and experimentally validated anticancer assays. CancerPPD includes: 3491 peptide entries 624 unique anticancer peptides 121 anticancer proteins 249 cancer cell lines 21 tissue types 16 experimental assay types The database also stores: Peptide structures SMILES representations Chemical modifications Secondary structure annotations Sequence and structural similarity information