Epitope mapping of gp-120-specific mAbs.
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Cross competition with biotinylated mAbs of known specificity or sCD4: +, 90–100% inhibition, +/−, 50–90% inhibition, −, <50% inhibition. The x indicates that it was not feasible to evaluate the competition due to the lack of binding to the immobilized gp120 protein. Binding by ELISA to YU2 gp120 wt and mutants in the CD4i and the CD4bs. Specificity assignment (CD4bs∼ indicates partial inhibition of sCD4 binding). Shown is also the number of isolates neutralized in the HOS-based and TZM-bl based assays.
创建时间：
2010-01-20
