Associations of five SNPs with parameters of glycaemia, insulin sensitivity, insulin secretion and proinsulin-to-insulin conversion (N = 1782).

Data represent means ± SEM for each genotype.aAlleles are listed in order of glycemic effect (known glucose-raising allele on the right) and the additive model was applied for all calculations. For the statistical analyses data were log-transformed.bPlasma glucose levels, ISI and HOMA-IR were adjusted for age, sex and BMI.cAll other parameters were adjusted for age, sex, BMI and ISI.dP values with nominal significance (eInsulin sensitivity index as proposed by Matsuda and de Fronzo.fHomeostasis model assessment index for insulin resistance.