RNA-sequencing of renal cells from Setd2-wildtype PKD and Setd2-knlckout ccRCC mice.
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https://www.ncbi.nlm.nih.gov/sra/SRP416168
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To explore potential role of SETD2 in PKD-ccRCC transition in vivo, we generated a PKD mouse model by overexpressing oncogene c-MYC under the control of the Ksp promoter (KM mice), and knockout Setd2 gene using the same Ksp promoter in this PKD mice (KMs mice) to establish a ccRCC mouse model. To further characterize biological responses trigered by SETD2 deletion during PKD-ccRCC transition at the mRNA level, we next conducted global transcriptomics studies. Overall design: Renal primary tubular epithelial cells mRNA profiles of five Kmmice and five KMS mice were generated by deep sequencing, in triplicate, using Illumina GAIIx.
创建时间：
2023-12-09
