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Somatic cell nuclear reprogramming by mouse oocytes endures beyond reproductive decline

ChEBI2011-08-15 更新2026-07-21 收录

细胞核重编程

卵母细胞衰老

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-23654 数据链接链接失效反馈

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Somatic cell nuclear reprogramming by mouse oocytes endures beyond reproductive decline

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创建时间：

2011-08-15

卵母细胞衰老

卵泡微环境

Reproductive aging is a major cause of fertility decline, attributed to decreased oocyte quantity and competence. Follicular somatic cells play crucial roles in the growth and development of the oocyt

NIAID Data Ecosystem70

Elevated intracellular pH appears in aged oocytes and causes oocyte aneuploidy associated with the loss of cohesion in mice

卵母细胞衰老

染色体非整倍性

Increases in the aneuploidy rate caused by the deterioration of cohesion with increasing maternal age have been well documented. However, the molecular mechanism for the loss of cohesion in aged oocyt

Figshare2016-09-09 更新40

S1 File -

卵母细胞衰老

NMN抗氧化干预

Oocyte senescence alters the shape and function, thereby weakening the fertilization potential. Nicotinamide mononucleotide (NMN) reverses age-related dysfunctions in various organs. Studies had shown

NIAID Data Ecosystem30

A Myc-dependent role for cohesin in the heterokaryon-mediated reprogramming of somatic nuclei. Mus musculus

细胞核重编程

层粘连蛋白调控机制

Analysis of gene expression changes in mESCs where the cohesin subunit Scc1 has been depleted. There are 6 samples. 3 Scc1 wt/wt ERT2-Cre biological replicas and 3 Scc1 lox/lox ERT2-Cre biological rep

NIAID Data Ecosystem60

CPEB1-dependent disruption of the mRNA translation program in oocytes during maternal aging

卵母细胞衰老

mRNA翻译调控

The molecular causes of deteriorating oocyte quality during aging are poorly defined. Since oocyte developmental competence relies on post-transcriptional regulations, we tested whether defective mRNA

NIAID Data Ecosystem40

Somatic cell nuclear reprogramming by mouse oocytes endures beyond reproductive decline

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