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WA PVL-positive bacteriophages and lysogens.
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2020-02-10
相关数据集
Quantification of phage competition between phages containing mutations in the seed or PAM-distal region of the gene L target.
Quantification of phage competition between phages containing mutations in the seed or PAM-distal region of the gene L target.
Figshare2023-04-14 更新60
Table_3_Insights Into the Impact of Small RNA SprC on the Metabolism and Virulence of Staphylococcus aureus.xlsx
AimOur previous proteomic analysis showed that small RNA SprC (one of the small pathogenicity island RNAs) of Staphylococcus aureus possesses the ability to regulate the expression of multiple bacteri
NIAID Data Ecosystem40
This study describes the target receptor and mechanism of action of Staphylococcal superantigen like 13 (SSL13), a secret protein reside on S.aureus immune evasion cluster 2(IEC-2) that previously supposed to modulate immune evasion. In sharp contrast to the characterized SSLs located on the staphylococcal pathogenicity island 2 (SPI-2) , that inhibit immune functions, We demonstrate SSL13 is a chemoattractant and a neutrophil activator that acts via the FPR2. Therefore, SSL13 is a unique SSL member not belonging to the immune evasion class, but is a pathogen alarming molecule sensed by the FPR2. Our study provides a new conception of SSLs, that not only inhibit host immune processes but also recruit human neutrophils to the site of infection, where S. aureus can be disarmed by secreted immune evasion proteins and used as vesicles to other parts of the host. This allow us to better understand of S. aureus pathological processes.
Staphylococcal Superantigen-Like (SSL) proteins, one of major virulence factor families produced by Staphylococcus aureus, were previously demonstrated to be immune evasion molecules that interfere wi
NIAID Data Ecosystem30
Summary of mycobacteriophage mutants generated with BRED.
1Mutations generated were gene deletions, insertion of C-terminal His6 tags, nonsense mutations, or replacement of phage gene with gfp (Replace). 2Plaques recovered from electroporation were analyzed
NIAID Data Ecosystem50
A prophage-encoded actin-like protein required for efficient viral DNA replication in bacteria
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
NIAID Data Ecosystem40
