Human hepatocytes can give rise to intrahepatic cholangiocarcinomas

To determine the transcriptomic similarity of undifferentiated carcinomas (UDCs) and intrahepatic cholangiocarcinomas (iCCAs) generated from primary human hepatocytes (phHeps) by oncogene expression and transplantation into immue-deficient mice with liver injury to iCCAs and hepatocellular carcinomas (HCCs) resected from patients. Overall design: Comparison of gene expression profile by RNAseq of phHep-derived UDCs 1-3 and phHep-derived iCCAs 4-12 to patient-derived ICCAs A-C and I-O and patient-derived HCCs D-H.