Validation of mRNA markers differentiating among human ARDS subgroups in an ovine model of ARDS phenotypes. Validation of mRNA markers differentiating among human ARDS subgroups in an ovine model of ARDS phenotypes

Comparison of a subset of mRNA markers previously discribed in leukocytes of human ARDS patients with lung tissue expression in ovine ARDS phenotype 1 and phenotype 2 models Overall design: 23 anesthetized sheep on mechanical ventilation were randomly allocated to one of two ARDS phenotypes (phenotype 1 (Ph1), hypoinflammatory or phenotype 2 (Ph2), hyperinflammatory) and observed for between 6 and 24 hours.