Clusters of ≥3 genes with statistically significant changes in expression common to Ea.hy926 endothelial cells infected with L. biflexa serovar Patoc and L. interrogans serovar Canicola.

1KEGG Pathways: http://www.genome.jp/kegg/pathway.html. The Table is arranged in order of descending p value for L. interrogans. The comparisons were made between cells infected with the indicated bacterial strain vs. uninfected controls at 1 hr. post infection. Similar trends were observed at the 3 hr. time point. Pathway abbreviations are provided for reference to Table 2. The same pathways also showed significant changes in expression, in similar patterns, in a second endothelial cell line, HMEC (data not shown).2P values considered to be statistically significant were (http://bioinfo.vanderbilt.edu/webgestalt).