Follicular lymphoma microenvironment characteristics associated with tumor cell mutations and MHC class II expression. Follicular lymphoma microenvironment characteristics associated with tumor cell mutations and MHC class II expression

Follicular lymphoma (FL) is a B-cell lymphoma with a complex tumor microenvironment that is rich in non-malignant immune cells. We applied single-cell RNA-sequencing to characterize the immune microenvironment of FL. This provides a classification framework of the FL microenvironment, their association with FL genotypes and antigen presentation, and informs different potential immunotherapeutic strategies. Overall design: scRNA-seq of 20 FL lymph node biopsies and three reactive lymph nodes (RLN) using the 10X Chromium platform to profile the transcriptome in addition to T-cell receptor (TCR) and immunoglobulin (Ig) repertoires. **RAW data has been uploaded to EGA. Accession EGAS00001006052.**