Overview of main findings and side effects of included studies.

OMT: Osteopathic Manipulative Treatment; SD: Standard Deviation; PEF: Peak Expiratory Flow; ANCOVA: Analysis of Covariance; FEF: Forced Expiratory Flow; RV: Residual Volume; TLC: Total Lung Capacity; IC: Inspiratory Capacity; TLP: Thoracic Lymphatic Pump; FVC: Forced Vital Capacity; MVV: Maximal Voluntary Volume; 6MWD: 6-minute walking Distance; PR: Pulmonary Rehabilitation; ABPI: Ankle/Brachial Pressure Index; CPT: Claudication Pain Time; TWT: Total Walking Time; FMV: Flow Mediated Vasodilation; sICAM: Soluble Intercellular adhesion molecule; sVCAM: Soluble Vascular Cell Adhesion Molecule; IL-6: Human Interleukin-6; IBS: Irritable Bowel Syndrome. As a secondary outcome authors measured the thoracic compliance. OMT groups significantly increased respiratory motion when compared to sham intervention groups. The mean change in upper and lower thoracic excursion was statistically significant between groups (Tables 1 and 2).Guiney et al [22] enrolled 140 asthmatic children (range 5–17 y) and randomly assigned to OMT group and sham control group. The main outcome was the baseline variation of PEF before and after treatment. Results demonstrated that OMT group significantly increase PEF rates compared to control (PEFOMT: 13.0 (27.4); PEFsham: 0.3 (35.5)). Within group analysis demonstrated that the OMT group moved from 7 L to 19 L/minute, whilst the control group did not change (10 L/minute) (Tables 1 and 2).Overview of main findings and side effects of included studies.