Comparison of PD+MSA enrichment for single- and multi-omics approaches.

For multi-omics (POPLS-DA and MINT) and single-omics (LASSO and t-test) approaches, the selected genes are tested for DisGeNet Parkinson’s disease and MSA enrichment. The FDR-corrected enrichment p-value is given in the second column. In the third column, the number of genes within the PD+MSA gene set out of the total number of selected genes is given. POPLS-DA and MINT were applied integratively (in bold italics) and individually to transcriptomics and proteomics data. The LASSO and t-test approaches were applied to transcriptomics and proteomics individually. Then, the selected genes and proteins were intersected (in italics).